Aida Laurinavičienė, Assoc. prof., PhD,
Head of Pathology Laboratory

Tel.  +370 5 247 73 59

2012 Vilnius University and VU Oncology Institute, biomedical, medicine, medical doctor 
2002 Vilnius University, Medical Sciences, Biomedical, a master's degree
1995 Vilnius University, Faculty of Nature Sciences, Biology, a Master's Degree
2011 “François Baclesse Comprehensive Cancer Centre of Caen”, France
2010 Nottingham image analysis training school
2007 Nijmegen, Nytherlands
2005 Oncology Institute, Gliwice, Poland
2001 „DAKO“  Cytomation, Glostrup, Denmark 
2001 Stavanger Regional Hospital, Norway      
2000 Frankfurt Pathology Center
1999 Boston Regional Medical Center, Harvard University, Brigham and Women's Hospital, USA
1997 Kuopio University, Department of Anatomy, Finland

ISI list of journals:

1. Besusparis J, Plancoulaine B, Rasmusson A, Augulis R, Green AR, Ellis IO, Laurinaviciene A, Herlin P, Laurinavicius A: Impact of tissue sampling on accuracy of Ki67 immunohistochemistry evaluation in breast cancer. Diagn Pathol 2016, 11(1):82.
2. Vaisnoriene I, Didziapetriene J, Zalgeviciene V, Laurinaviciene A, Vaisnoras T, Kulvietis V, et al. Reflectance confocal microscopy (RCM) and melanocyte-specific immunostaining of histologic skin sections. J Am Acad Dermatol. 2016;75(2):439-40.
3. Laurinavicius A, Plancoulaine B, Rasmusson A, Besusparis J, Augulis R, Meskauskas R, et al. Bimodality of intratumor Ki67 expression is an independent prognostic factor of overall survival in patients with invasive breast carcinoma. Virchows Arch. 2016;468(4):493-502.
4. Laurinavicius A, Plancoulaine B, Herlin P, Laurinaviciene A: Comprehensive immunohistochemistry: digital, analytical and integrated. Pathobiology special issue. Pathobiology. 2016;83(2-3):156-63.
5. Laurinavicius A, Plancoulaine B, Rasmusson A, Besusparis J, Augulis R, Meskauskas R, Herlin P, Laurinaviciene A, Abdelhadi Muftah A, Miligy I, Aleskandarany M, Rakha EA, Green AR, Ellis IO: Bimodality of intratumor Ki67 expression is an independent prognostic factor of overall survival in patients with invasive breast carcinoma. Virchows Arch 2016, Volume 468, Issue 4, pp 493-502.
6. Laurinavicius A, Green AR, Laurinaviciene A, Smailyte G, Ostapenko V, Meskauskas R, Ellis IO: Ki67/SATB1 ratio is an independent prognostic factor of overall survival in patients with early hormone receptor-positive invasive ductal breast carcinoma. Oncotarget 2015.
7. Plancoulaine B, Laurinaviciene A, Herlin P, Besusparis J, Meskauskas R, Baltrusaityte I, Iqbal Y, Laurinavicius A: A methodology for comprehensive breast cancer Ki67 labeling index with intra-tumor heterogeneity appraisal based on hexagonal tiling of digital image analysis data. Virchows Arch 2015.
8. Maciulaitis J, Deveikyte M, Rekstyte S, Bratchikov M, Darinskas A, Simbelyte A, Daunoras G, Laurinaviciene A, Laurinavicius A, Gudas R, et al: Preclinical study of SZ2080 material 3D microstructured scaffolds for cartilage tissue engineering made by femtosecond direct laser writing lithography. Biofabrication 2015, 7:015015.
9. Plancoulaine B, Laurinaviciene A, Meskauskas R, Baltrusaityte I, Besusparis J, Herlin P, Laurinavicius A: Digital immunohistochemistry wizard: image analysis-assisted stereology tool to produce reference data set for calibration and quality control. Diagn Pathol 2014, 9 Suppl 1:S8.
10. Laurinaviciene A, Plancoulaine B, Baltrusaityte I, Meskauskas R, Besusparis J, Lesciute-Krilaviciene D, Raudeliunas D, Iqbal Y, Herlin P, Laurinavicius A: Digital immunohistochemistry platform for the staining variation monitoring based on integration of image and statistical analyses with laboratory information system. Diagn Pathol 2014, 9 Suppl 1:S10.
11. Vaisnoriene I, Rotomskis R, Kulvietis V, Eidukevicius R, Zalgeviciene V, Laurinaviciene A, Venius J, Didziapetriene J: Nevomelanocytic atypia detection by in vivo reflectance confocal microscopy. Medicina (Kaunas) 2014, 50:209-215.
12. Daunoravicius D, Besusparis J, Zurauskas E, Laurinaviciene A, Bironaite D, Pankuweit S, Plancoulaine B, Herlin P, Bogomolovas J, Grabauskiene V, Laurinavicius A: Quantification of myocardial fibrosis by digital image analysis and interactive stereology. Diagn Pathol 2014, 9:114.
13. Laurinavicius A, Plancoulaine B, Laurinaviciene A, Herlin P, Meskauskas R, Baltrusaityte I, Besusparis J, Dasevicius D, Elie N, Iqbal Y, Bor C: A methodology to ensure and improve accuracy of Ki67 labelling index estimation by automated digital image analysis in breast cancer tissue. Breast Cancer Res 2014, 16:R35.
14. Stuopelyte K, Daniunaite K, Laurinaviciene A, Ostapenko V, Jarmalaite S: High-resolution melting-based quantitative analysis of RASSF1 methylation in breast cancer. Medicina (Kaunas) 2013, 49:78-83.
15. Arvydas Laurinavicius, Justinas Besusparis, Justina Didziapetryte, Gedmante Radziuviene, Raimundas Meskauskas, Aida Laurinaviciene: Digital immunohistochemistry: new horizons and practical solutions in breast cancer pathology Diagnostic Pathology 2013, 8(Suppl 1): S15, DOI: 10.1186/1746-1596-8-S1-S15.
16. Laurinavicius A, Laurinaviciene A, Ostapenko V, Dasevicius D, Jarmalaite S, Lazutka J: Immunohistochemistry profiles of breast ductal carcinoma: factor analysis of digital image analysis data. Diagn Pathol 2012, 7:27.
17. Laurinavicius A, Laurinaviciene A, Dasevicius D, Elie N, Plancoulaine B, Bor C, Herlin P: Digital image analysis in pathology: benefits and obligation. Anal Cell Pathol (Amst) 2012, 35:75-78.
18. Laurinaviciene A, Dasevicius D, Ostapenko V, Jarmalaite S, Lazutka J, Laurinavicius A: Membrane connectivity estimated by digital image analysis of HER2 immunohistochemistry is concordant with visual scoring and fluorescence in situ hybridization results: algorithm evaluation on breast cancer tissue microarrays. Diagn Pathol 2011, 6:87.
19. Jarmalaite S, Laurinaviciene A, Tverkuviene J, Kalinauskaite N, Petroska D, Bohling T, Husgafvel-Pursiainen K: Tumor suppressor gene ZAC/PLAGL1: altered expression and loss of the nonimprinted allele in pheochromocytomas. Cancer Genet 2011, 204:398-404.

Other refereed publications:

20. J. Tverkuviene, A. Laurinaviciene, K. Daniunaitė, A. Scesnaite, S. Jarmalaite: Frequent aberrant DNA methylation of CDKN2A locus in capillary hemangioblastomas, pheochromocytomas and gliomas. Acta Medica Lithuanica, 2011. Vol. 18. No. 1. P. 4–11.
21. A. Laurinaviciene, D. Petroska, J. Tverkuviene, K. Daniunaite, A. Scesnaite, S. Jarmalaite: Frequent aberrant expression of p53 protein in gliomas, but not in capillary hemangioblastomas and pheochromocytomas. Acta Medica Lithuanica, 2009 Vol. 16. No. 3–4. P. 130–138.
22. Česas A., Stratilatovas E., Laurinavičienė A. Biožymenų svarba gydant kolorektalinį vėžį biologine terapija cetuksimabu. Onkologija: žurnalo Internistas priedas. 2009; 4:58-59.

Biomedicine: tumor tissue biomarker studies immunocytochemistry, fluorescence in situ hybridization and others. molecular methods for analyzing digital pathology.